The diversity of biological samples in terms of compound structure and properties coupled with matrix complexity demands a range of sample separation modes, column chemistries, column configurations and detection techniques for their effective characterization. The Thermo Scientific BioBasic family of HPLC columns addresses these needs with a range of reversed phase, ion exchange and SEC columns, specifically designed to handle the unique rigors of the analysis of proteins, peptides and other biomolecules. The 300 Å pore size, high purity silica and stable bonding chemistry of BioBasic packings makes them ideal for life science applications.