To address the diversity of microplate washing requirements, BioTek has developed the ELx405™, a family of microplate washers that provides versatility, as well as dedicated capabilities. The ELx405 Select Microplate Washer uses a patented manifold design which provides independent control of aspirate and dispense tube location and height enabling bubble free fluid dispense and overflow protection in 96- and 384-well plates. Other models include the ELx405™ HT, which is a dedicated 384-well microplate washer, based on the same manifold design. The ELx405 Select CW was designed to wash loosely adherent cells, while the ELx405 Magna can be used for magnetic bead assays. Maintenance problems have been reduced by the introduction of the patent-pending Ultrasonic Advantage™ design, which provides ultrasonic cleaning of the manifold on most ELx405 washers. An overview of the ELx405 washer family, data demonstrating the washer’s accuracy and precision, evacuation efficiency, as well as speed and timing will be included.