Molecular Devices - CellKey 384 System
Provides high-throughput, label-free, cell-based assay technology.
Complete CellKey™ System benefits, plus 384-well advantages
Give your drug discovery process the benefit of a proven universal platform that streamlines assay development by monitoring the activation of different classes of cellular targets. Obtain unique kinetic response data that simplifies the process of signal pathway identification and deconvolution.
Active Questions & AnswersAsk a Question
There are no current Discussions
Protein Analyzers Service ProvidersView All (1)
Documents & ManualsView All Documents
Features of CellKey 384 System
Our automation-friendly technology, integrated fluidics, and analysis software, are now available in 384-well format. Along with the robust, reproducible data you’ve come to expect, the CellKey™384 System delivers
- Rapid kinetic assay results in as little as 15 minutes or even less—not hours or days.
- Simultaneous fluidics during measurement, that allows you to capture valuable fast kinetic response data, with no loss of information.
- Label-free, screening-compatible format with higher speed and throughput, for cell-based kinetic screening—typically 24,600 wells in an eight-hour period.
- Low reagent and sample volumes in a small benchtop footprint.
Features and Benefits
Reliable measurement of endogenous receptors: The CellKey™384 System sensitivity allows biorelevant measurements of receptor activity in cell lines and primary cells. Label free: Expensive tags, dyes, or specialized reagents are not required. Unique kinetic response data: CellKey™ response profiles directly correlate to receptor mediated signal transduction pathways, thus enabling identification of the underlying mechanism of action of lead compounds. Universal platform: Single platform and assay methodology measures both G protein-coupled receptors (GPCRs) and tyrosine kinase receptors (TKRs). Streamlined assay development: Costly and time consuming biological manipulation of cell lines is avoided. Also, single-assay format can be used for multiple receptor types regardless of signal coupling mechanism. Ease of use: The CellKey™384 System is a fully integrated, flexible and intuitive platform.
General Specifications
Depth | 23 in |
Height | 28 in |
Width | 39 in |
Weight | 320 lbs |
Additional Specifications
Measurements
Assay type: Homogenous, label-free, cell-based
Principles: Impedance
Frequency range: 1 kHz–10 MHz
Mode: Kinetic measurement: simultaneous sample addition and measurement across all wells
Data acquisition rate: 4 or 20 second update rate
Fluidics
Simultaneous transfer: 384 well
Pipettor range: 0.5–25 µL
Pipetting increments: 0.1 µL
Additional standard features: Compound mix capability, tip wash capability
Throughput
Assay development: 4 plates/hour (15-minute read time)
High-throughput: 8 plates/hour or better (5-minute read time, plus automation)
Plate Stage
Temperature control: Ambient +5° to 37°C (below 20°C, ambient +6°)
Deck positions: One read position, two compound plate positions, one tip loading position
General Specifications
Tip wash control unit weight: 16 kg/35 lbs
Tip wash control unit dimensions (in): 19 (H) x 8 (W) x 12 (D)
Power Supply: 100–120/200–240 V (self-adjusting) 50/60 Hz, 700 W consumption
Computer
Processor: Intel Core™2 Dual Core 2.66 GHz, 2 GB RAM
LCD monitor: 20-inch
Operating system: Windows® XP