Modern HRAM nano-ESI MS analysis is putting increased pressure on the front-end LC separation to match the MS in terms of robustness and reliability as well as demanding the absolute highest quality and reproducibility of sample separation.  To ensure such individual system performance as well as consistency over multiple systems and/or labs, deeper system integration and novel approaches to quality control as well as intelligent system diagnostics are called for. This in turns requires rigorous protocols and automation for all phases of the experiment, driving new approaches to user interface design and data monitoring, as well as a critical rethink of all flow paths and liquid handling parts of the configuration.

The Bruker nanoElute is designed with years of proteomics know-how and nano-UHPLC expertise.

Based on industry leading components coupled with innovative solutions to common problems, it delivers trouble-free operation from the moment of installation through years of OMICS knowledge generation.

When paired with the ultra high-resolution / accurate mass QqTOF, the Bruker impact II and the market proven CaptiveSpray ionization source, the nanoElute System is unbeatable when it comes to:

• Data-dependent and data-independent bottom-up proteomics
• Proteoform profiling for biomarker discovery and Validation
• Intact protein characterization
• Glyco- and phospho-proteomics

The complexity of the nanoElute’s built-in intelligence and applied chromatographic understanding is hidden behind a user interface that is intuitive and easy to use, but also powerful and flexible to operate.