MS imaging is becoming more popular for various application areas such as clinical research and pathology in order to compare cancerous areas with non-cancerous ones, or in the pharmaceutical field to look for a drug's distribution and their metabolites in a tissue. The quality and reproducibility of sample preparation for Mass Spectrometry Imaging (MSI) has limited the widespread acceptance of this technique. iMLayer, a sample preparation device for MSI, uses vapor deposition to deposit submicron matrix crystals onto tissue sections in a very controlled manner. Using this innovative technique of matrix sublimation, researchers are able to take advantage of the high spatial resolution that the MALDI-7090 can achieve.