ProImmune - ProM2®

Manufactured by  ProImmune
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Traditional functional assays for studying antigen-specific CD4+ T cells, such as proliferation or cytokine secretion,...

Traditional functional assays for studying antigen-specific CD4+ T cells, such as proliferation or cytokine secretion, are not truly antigen-specific. The detection of CD4+ T cells has been difficult, due to the low frequency of these T cells (down to 1 in 100,000 white blood cells) and the low avidity of binding between the MHC-peptide binding complex and the T cell receptor. The optimized manufacturing process for ProM2® Class II MHC Monomers helps to address these issues by improving reproducibility and sensitivity of CD4+ T cell detection. 
 
ProImmune provides ProM2® Class II MHC Monomers with responsive, expert technical support and customer service. Contrary to ordering class II tetramers from in-house or non-commercial facilities, customers do not need to apply and wait for reagents or supply any peptide. ProM2® Class II MHC Monomers are delivered quickly with stringent quality control and low batch-to-batch variability. As such ProM2® Class II MHC Monomers complement ProImmune’s existing Pro5® Class I Pentamer technology for detecting antigen-specific CD8+ T cells.
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Features of ProM2®

From the most experienced commercial providers of MHC multimers 

Proven technology for detecting antigen-specific T cells 

Broadest range of catalog items available 

Flexible labelling options 

Long-term storage 

Industry leading customer service from immunologists who understand your work

General Specifications

There are no General Specifications available.

Additional Specifications

Available Quantities 
 
35ug, 100ug. 
 
Fluorescent Label 
 
ProM2® Class II MHC Monomers are delivered in kit form with a choice of standard R-PE or APC labelled streptavidin to conjugate to. Alternatively customers can conjugate ProM2® Monomers to any other suitable avidin or streptavidin reagent. 
 
Catalog ProM2® Class II MHC Monomers 
 
A broad range of MHC Class II complexes specific for a wide range of infectious diseases such as Influenza, CMV, hepatitis B and C, HIV, EBV, as well as cancer-related epitopes are available as ProM2® Monomers. Catalog ProM2® Monomers are despatched in 1-2 days for Stock items, and 3 weeks for Available items. 
 
 
Custom ProM2® Class II MHC Monomers 
 
Custom ProM2® Monomers for your allele/peptide of interest are available within approximately 6-7 weeks from ordering. Peptide sequences are subject to prior evaluation by ProImmune for binding. Once a peptide sequence is accepted for custom synthesis we will synthesize both the peptide and MHC monomer reagent. 
 
Available Alleles 
 
HLA-DR1 (DRB1*01:01); DR2 (DRB1*15:01); DR3 (DRB1*03:01); DR4 (DRB1*04:01); DRB1*04:02 
 
DRB1*04:05; DR5 (DRB1*11:01); DR7 (DRB1*07:01); DR9 (DRB1*09:01) 
 
Fully compatible technology 
 
ProM2® Class II MHC Monomers can be used together with other Class II Tetramer reagents which customers may already have established in their labs.

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