Sphere Fluidics - Cyto-Mine
There are a number of different techniques that are routinely used in the biopharmaceutical discovery and development...
Our Cyto-Mine® technology is the first integrated device to be able to automatically perform all of these crucial techniques in a single compact system. This high-throughput instrument uses picodroplet technology and microfluidics to process upto 10 million heterogeneous mammalian cells in less than half a day. Each cell is encapsulated in a picodroplet containing growth media, which acts as a bioreactor to compartmentalise the cell and let it grow; eventually trapping secreted molecules such as antibodies. The unique workflow enables selective screening of single cells to find rare lead candidates.
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Since the single cells are compartmentalised, monoclonality is ensured and you can perform novel assays to determine protein secretion rates, titre and antigen-specificity. The disposable Cyto-Cartridge® used with Cyto-Mine® gives you confidence of sterility and minimises crossover risks. Automation of the system reduces human resource requirements and the simple ‘load-and-go’ format makes it easy to use by everyone in the lab. Cyto-Mine®, Cyto-Cartridge® and our specialist chemicals and bioreagents are all Animal-Origin Free and GLP-compliant.
There are three main application modes for the Cyto-Mine® system: