For the isocratic UPLC analysis of analytes without a UV chromophore, the ACQUITY UPLC Refractive Index (RI) Detector offers unparalleled performance. Its low-dispersion fluidics are designed to match the performance needed for narrow UPLC peaks while still delivering stable baseline performance, low noise, and a wide, linear dynamic range.  
 
Refractive index detection is one of the key enabling technologies in the ACQUITY Advanced Polymer Chromatography (APC) System. The low-dispersion characteristics of the ACQUITY UPLC RI Detector are critical for maintaining the high-resolution molecular weight separations achieved on the ACQUITY APC columns, delivering unprecedented characterization of low molecular weight polymers and their oligomers. 
 
HPLC/RI applications, including sugars, alcohols, saccharides, and pharmaceutical QC, can easily be transferred to UPLC system technologies to enable improved resolution and reduced analysis times.