serial dilutions  TTP Labtech’s mosquito HTS can create 500 nL to 2 ΜL total volume serial dilutions, automatically dispensing at high speed. For example, an 11 point low volume dilution series can be dispensed in 1.5 minutes. 

plate reformatting and replication  TTP Labtech’ s mosquito HTS liquid handling robot enables easy and accurate reformatting between 96-, 384- and 1536-well plates, including replicating mother plates directly into high-density, low-volume daughter plates within 1.5 mins. 

acoustic source plate creation  Fast plate set-up, excellent sample recovery and integrated plate seal piercing makes mosquito HTS a very efficient tool for acoustic source plate creation. 

next generation sequencing  TTP Labtech’s mosquito HTS offers an accurate and easy to use solution which can be applied to miniaturising next generation sequencing (NGS) reaction volumes within an automated, high throughput setting. Additionally, it offers ability to pipette liquids with high viscosities (such as enzymes in 50% glycerol) accurately and precisely with no cross contamination. It provides a unique opportunity to obtain the current level of data at a significantly lower cost, and/or to carry out larger scale studies at current costs. 

genotyping  PCR and qPCR is expensive. By miniaturising the assay, TTP Labtech’s mosquito nanolitre liquid handling capabilities can reduce the reagent cost of real-time PCR and SNP genotyping by up to 90%. In addition mosquito’s disposable micropipettes have the added benefit of eliminating cross-contamination. 

high-throughput MALDI-TOF MS  mosquito HTS has been integrated into the fastest, automated mass spectrometry system for biochemical screening, designed to accelerate all phases of drug discovery. The MALDI PharmaPulse incorporates Bruker Daltonics’ autoflex speed MALDI-TOF system with robotic sample preparation and movement provided by TTP Labtech and HighRes Biosolutions. The system offers true label-free detection of native substrates and products in functional biochemical screens. 

mosquito HTS provides low volume, high precision liquid handling and pipetting compatible with 96, 384 and 1536 formats. mosquito’s unique positive displacement technology allows sample and matrix to be sequentially aspirated and simultaneously dispensed to produce uniform, homogeneous spots in the sub microliter range. Highly accurate pipetting and positioning allows spots to be set up in high density 1,536 arrays to enable fast and efficient analysis. The homogeneous nature of the spots mean the MALDI laser can always fire in the same location without compromising data quality/signal strength and is key to the overall throughput of the system. The rigid nature of the tips also allows them to pierce foil-sealed source plates, which is essential for the preservation of volatile matrix and wash solutions. mosquito HTS is capable of preparing a 1,536 MALDI plate in less than 1 second per well – keeping pace with analysis time of the MALDI-TOF and maintaining overall throughput.