Thermo Scientific - BioPharma Finder™

Manufactured by  Thermo Scientific
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Mass Informatics Platform for Protein Characterization

Save time and identify more with Thermo Scientific™ BioPharma Finder™ integrated software. Screen, identify and characterize intact proteins with higher productivity and confidence using Intact Protein workflow. Two deconvolution algorithms take full advantage of the high-quality, HRAM data produced by Thermo Scientific™ Orbitrap™ mass spectrometers. Confirm amino acid sequence, identify site and type of known/unknown PTMS while providing relative amounts using Peptide Mapping workflow. Additional features include disulfide linkage, sequence variant analysis and sequence alterations.
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Features of BioPharma Finder™

All of your protein characterization challenges can be met through the extensive capabilities of our new biopharmaceutical platform solution, BioPharma Finder. 

Workflow-driven experiment creation, method processing, and result review. The intact protein workflow provides: 

  • Rapid measurement of the intact molecular weight of biotherapeutics for structural confirmation and characterization. 
  • Confident deconvoluted molecular weight of proteins in both acidic and native conditions. 
  • Target protein sequence matching, which identifies n-linked glycosylations and other common modifications using the intact mass. 
  • Identification of Antibody Drug Conjugates (ADC) using sliding window algorithm. 
  • Batch-to-batch comparison. 

The peptide mapping workflow provides: 

  • Confirmation of amino acid sequence with a novel MS2 prediction algorithm, providing extra confidence in your peptide sequence assignments. 
  • Identification of the site and type of expected and unknown PTMs, providing the relative amount of modification in the sample. 
  • Disulfide bond mapping. 
  • Detection of low level impurities and sequence variants. 
  • Sequence alterations in stress samples, including the level of deamidation or oxidation. 
  • Error tolerant searches for unexpected modifications. 
  • De novo sequence searches for unknown components.
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